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KMID : 0363320130340010059
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Journal of Korean Oriental Internal Medicine
2013 Volume.34 No. 1 p.59 ~ p.70
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The Effect of Warm Environment and Bujaijung-tang on Immune and Lipid Metabolism in Rats
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Noh Hyun-In
Yoon Da-Rae
Lee Seo-Ra
Lee In-Hee
Hong Sung-In
Lew Jae-Hwan
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Abstract
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Objectives : This study was designed to test the effect of a warm environment and Bujaijung-tang on immune and lipid
metabolism in rats.
Methods : The extract from Bujaijung-tang was made by the pharmacy department of Kyung-Hee oriental medical hospital. The animals were divided into four groups, by room or warm environment and Bujaijung-tang administration. Each group had 8 Sprague-Dawley Rats. We measured body temperature twice a week, body weight three times a week. After 3 weeks of experiment, serum lipid level, WBC, differential count, lymphocyte proliferation and immune cytokine concentration were measured.
Results : 1. warm environment induced weight loss in rats. 2. warm environment induced a decrease of total cholesterol and low-density lipoprotein (LDL) cholesterol gain. 3. warm environment and Bujaijung-tang induced an increase of tumor necrosis factor (TNF)-α concentration.
Conclusions : The warm environment had a hyperlipidemia modulating effect. The warm environment and Bujaijung-tang had an immune modulating effect.
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KEYWORD
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warm environment, Bujaijung-tang, body weight, lipid, immune, TNF-α
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